Eagles right tackle Lane Johnson will miss his eighth consecutive game with a foot injury. Johnson participated on a limited basis in practice all week, but will have to wait for the Eagles to advance for a chance to play again this season. Fred Jackson is expected to start in his place.
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49ers left tackle Trent Williams did not play in Week 18 due to a hamstring injury, but will return to the lineup on Sunday. Linebacker Luke Gifford (quadriceps), wide receiver Ricky Pearsall (knee, ankle) and linebacker Dee Winters (ankle) are inactive after joining Williams in the questionable category.
Defensive tackle Kevin Givens, receiver Jordan Watkins, cornerback Chase Lucas and running back Isaac Guerendo are the other inactive 49ers.
Edge rusher Joshua Uche, quarterback Sam Howell, cornerback Jakorian Bennett, running back AJ Dillon, offensive lineman Brett Toth and defensive lineman Ty Robinson join Johnson as inactive for the Eagles.