The competition, scheduled for May in Las Vegas, will allow athletes to consume, under medical supervision, substances prohibited in conventional sports.
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The 29-year-old, who retired last year, is the fourth-fastest Briton over 100 metres, with a personal best of 9.93 seconds.
Speaking to BBC Radio 4’s World at One programme, Prescod answered “no” when asked if he had used any substances so far.
Asked “But will you?” he again replied: “No.”
“Obviously from a medical point of view it’s always confidential, but I think for me right now the biggest priority is getting back to that under-10 form,” he added.
The Enhanced Games have been criticized for endangering athletes’ health and undermining fair play, with the World Anti-Doping Agency (WADA) describing them as a “dangerous and irresponsible project”.
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Only substances approved by the United States Food and Drug Administration (FDA) can be taken. This is a different list than the one that WADA allows for elite athletes.
UK Athletics chief executive Jack Buckner said he was “horrified” when it was revealed Prescod had signed up in early January.
Prescod said participants, who also included former British Olympic swimmer Ben Proud, had a “personal choice” about the measures they took.
In September, Proud said organizers “aren’t asking me to take anything” and added that he wasn’t sure if he would use any substances.
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“People aren’t necessarily aware that it’s actually a choice that you have. Some athletes will improve, some won’t,” Prescod said.
“I started my winter preparation as I normally would for a track season.”
“Exciting” perspective
When asked if he would put himself at a disadvantage, Prescod said he had “raced (for) 12 or 15 years completely clean without any infractions” and had run under 10 seconds “on quite a few occasions.”
Asked if he was “excited” by the idea that there are things he and his rivals could do to help each other go faster, Prescod said: “I think the prospect is definitely exciting, but that’s more like the icing on the cake.
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“It’s not necessarily the basis of what you need to do to prepare for the 100 meters.”
He suggested that “preparation” and “technique” would be key factors in determining its success.
“I know I’m capable of a certain level of speed,” he explained.
“But again, the medical team we have is very good and the improvements are there if that is the option you want to take.”
Prescod (right) reached the 100 meters semi-finals at the 2020 Tokyo Olympics (Getty Images)
After news broke that Prescod would join the Enhanced Games, UKA said it did not recognize the Enhanced Games as a “legitimate sporting competition” and that it “places the health and well-being of athletes at serious risk”, adding that it was “disappointed” by its decision to participate.
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In response, Prescod said he had “no hard feelings” with the organization and argued that he “hadn’t necessarily gotten all the information.”
He has welcomed the opportunity to participate in sprinting again, feeling that he still has “a few years left on the track” despite his retirement.
“I retired because I lacked support,” he said. “I asked industry sponsors, sent several emails, spoke to all the agents and told them if there was any opportunity to continue and the answer was ‘no.’
“As a 100m athlete, it’s not a cheap sport. You need funding for your coach, travel and support staff. There are so many costs in athletics that people don’t necessarily know about.
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“It’s like working full time and not having a salary. You just can’t do it.”
What are enhanced games?
The Enhanced Games will take place May 21-24, 2026 in Las Vegas and is planned to be an annual event.
Organizers have billed it as a celebration of “human potential through safe and transparent improvement, offering fair play, record pay and unmatched athlete care,” but Travis Tygart, executive director of the United States Anti-Doping Agency, called it a “clown show.”
The event offers appearance fees and bonuses, and Greek swimmer Kristian Gkolomeev received a $1 million (£739,000) prize for breaking a world record in the US in February last year.
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Organizers said he swam 20.89 seconds in a 50-meter freestyle time trial, 0.02 seconds faster than the world record set by Brazilian Cesar Cielo in December 2009, although the time will not be recognized by World Aquatics.
Other athletes who have joined include American sprinter Fred Kerley and former Australian world swimming champion James Magnussen.