Serah Williams scored 10 points, Azzi Fudd had nine points and five of her season-high 25 steals for the Huskies (3-0). Allie Ziebell also scored nine points.
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Alexa Kinas and Alex-Anne Bessette scored seven points for Loyola (1-2).
Nine UConn players scored a field goal in the first half as the Huskies led 41-14 at halftime.
Things only got worse for Loyola after the break. The Ramblers did not score for the final 9:46 of the third quarter, after opening the quarter with a three-pointer by Kinas, and went 11:35 without making a field goal.
Loyola is the 184th program UConn has defeated since Geno Auriemma took over as coach in 1985.
Freshmen Blanca Quiñonez and Gandy Malou-Mamel made their UConn debuts after missing the first two games of the season. Quiñónez scored five points, three rebounds and two steals in 14 minutes. Malou-Mamel played the last 1:47, but did not score.
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UConn announced the signing of Olivia Vukosa on Wednesday. The 6-foot-4 Vukosa is the No. 5-rated player in the Class of 2026 by Prospects Nation. Vukosa is a star at Christ the King in New York, the same program that produced UConn stars and national player of the year winners Sue Bird and Tina Charles.
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Loyola: The Ramblers will play Maryland-Eastern Shore at home on Sunday.
UConn: The Huskies host Ohio State on Sunday.
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